Heat inactivation of the Middle East respiratory syndrome coronavirus

被引：103

作者：

Leclercq, India ^{[1
,2
]}

Batejat, Christophe ^{[1
]}

Burguiere, Ana M. ^{[1
]}

Manuguerra, Jean-Claude ^{[1
]}

机构：

[1] Inst Pasteur, Environm & Infect Risks Unit, Lab Urgent Response Biol Threats CIBU, F-75724 Paris 15, France

[2] Univ Paris Diderot, Sorbonne Paris Cite Cellule Pasteur, Paris, France

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2014年 / 8卷 / 05期

关键词：

Heat; inactivation; MERS-CoV;

D O I：

10.1111/irv.12261

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The culture supernatants of the emerging Middle East respiratory syndrome coronavirus (MERS-CoV) were submitted to three temperatures over time and tested for infectivity by TCID50 method on Vero E6 cells. At 56 degrees C, almost 25minutes were necessary to reduce the initial titre by 4log(10). Increasing temperature to 65 degrees C had a strong negative effect on viral infectivity as virucidy dropped significantly to 1minute. On the contrary, no significant decrease in titre was observed after 2hours at 25 degrees C. These data might be useful in establishing biosafety measures in laboratories against MERS-CoV.

引用

页码：585 / 586

页数：2

共 5 条

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