Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation

被引：15

作者：

Cheng, HW ^{[1
]}

Jiang, T ^{[1
]}

Mori, N ^{[1
]}

McNeill, TH ^{[1
]}

机构：

[1] UNIV SO CALIF, DEPT CELL NEUROBIOL, LOS ANGELES, CA 90089 USA

来源：

NEUROREPORT | 1997年 / 8卷 / 17期

关键词：

cortical ablation; neural plasticity; phosphoprotein; stathmin;

D O I：

10.1097/00001756-199712010-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

STATHMIN (p19) is developmentally regulated as a neural-enriched phosphoprotein associated with neurite outgrowth and synaptic formation during cell proliferation and differentiation, and remains highly abundant in adult rat brain. Whether stathmin is involved in injury-induced reactive synaptogenesis in adult rat was examined in this study. Following unilateral cortical lesion, a significant increase in stathmin mRNA expression was found in the cells of contralateral homotypic cortex and in the subventricular zone of the lateral ventricle. This increase coincided in time with the corticostriatal axon sprouting and synaptic remodeling previously found in denervated striatum. Our data suggest that stathmin plays an important role in regulation of reactive synaptogenesis in adult brain.

引用

页码：3691 / 3695

页数：5

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