Titration of alkyllithiums with a simple reagent to a blue endpoint

被引:154
作者
Burchat, AF [1 ]
Chong, JM [1 ]
Nielsen, N [1 ]
机构
[1] UNIV WATERLOO,GUELPH WATERLOO CTR GRAD WORK CHEM,DEPT CHEM,WATERLOO,ON N2L 3G1,CANADA
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/S0022-328X(97)00143-5
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Reaction of readily available N-benzylbenzamide (1) with a slight excess of BuLi produces a deep blue dianion. Under suitable conditions (THF, -40 degrees C), 1 may be used as a stoichiometric reagent to titrate n-BuLi, s-BuLi, and t-BuLi with good precision. Less reactive alkyllithiums (MeLi and MeLi . LiBr), aryllithiums, and LDA may be titrated at higher temperatures (-20 to 0 degrees C). Titres are comparable to those obtained using the Gilman double titration method, and there appears to be no interference from alkoxides. (C) 1997 Elsevier Science S.A.
引用
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页码:281 / 283
页数:3
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