Chromosome imbalances in oligodendroglial tumors detected by comparative genomic hybridization

被引：10

作者：

Bourdon, V

Plessis, G

Chapon, F

Guarnieri, J

Derlon, JM

Jonveaux, P

机构：

[1] CHU Nancy Brabois, Genet Lab, F-54111 Vandoeuvre Les Nancy, France

[2] CHU Caen, Dept Genet & Reprod, F-14000 Caen, France

[3] CHU Caen, Neuropathol Lab, F-14000 Caen, France

[4] CHU Caen, Serv Neurochirurg, F-14000 Caen, France

来源：

ANNALES DE GENETIQUE | 2004年 / 47卷 / 02期

关键词：

oligodendroglial tumors; comparative genomic hybridization;

D O I：

10.1016/j.anngen.2003.10.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Seven well-differentiated oligodendrogliomas, 16 anaplastic oligodendrogliomas and two cases of oligoastrocytomas were investigated by comparative genomic hybridization (CGH) on frozen tissue samples. The most frequent losses found involved I p and 19q in 32% of cases. Loss of 9p was observed during malignant progression in 25% of anaplastic oligodendrogliomas. In two anaplastic oligodendrogliomas gain of 1q was found. The frequent losses of chromosome 16 and 22 have not been reported previously. These results underscore that CGH is a powerful tool for the classification of gliomas complementing the traditional histopathological approach. Published by Elsevier SAS.

引用

页码：105 / 111

页数：7

共 10 条

[1]

[Anonymous], 2000, World Health Organisation Classification of Tumours: Pathology and genetics of tumours of the nervous system

[2]

Bigner S H, 1999, Neuro Oncol, V1, P52, DOI 10.1093/neuonc/1.1.52

[3] Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization [J].