Myomaker is essential for muscle regeneration

被引：148

作者：

Millay, Douglas P. ^{[1
]}

Sutherland, Lillian B. ^{[1
]}

Bassel-Duby, Rhonda ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Harmon Ctr Regenerat Sci & Med, Dept Mol Biol, Dallas, TX 75390 USA

来源：

GENES & DEVELOPMENT | 2014年 / 28卷 / 15期

基金：

美国国家卫生研究院;

关键词：

myomaker; fusion; muscle regeneration; myogenesis; E-box elements; NORMAL MYOBLAST FUSION; SATELLITE CELLS; MOUSE; MYOGENESIS; ADHESION; GENOME; MYOD;

D O I：

10.1101/gad.247205.114

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Regeneration of injured adult skeletal muscle involves fusion of activated satellite cells to form new myofibers. Myomaker is a muscle-specific membrane protein required for fusion of embryonic myoblasts, but its potential involvement in adult muscle regeneration has not been explored. We show that myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration. Moreover, genetic deletion of myomaker in adult satellite cells completely abolishes muscle regeneration, resulting in severe muscle destruction after injury. Myomaker is the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult myoblasts.

引用

收藏

页码：1641 / 1646

页数：6

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