High effectiveness of efavirenz-based highly active antiretroviral therapy in HIV-1-infected patients with fewer than 100 CD4 cells/μl and opportunistic diseases:: the EfaVIP Study (Efavirenz in Very Immunosuppressed Patients)

被引：19

作者：

Arribas, JR ^{[1
]}

Pulido, F

Miró, JM

Costa, MA

González, J

Rubio, R

Peña, JM

Torralba, M

Lonca, M

Lorenzo, A

del Palacio, A

Vázquez, JJ

Gatell, JM

机构：

[1] Univ Madrid, Hosp 12 Octubre, Internal Med Serv, Madrid, Spain

[2] Univ Barcelona, Inst Invest Biomed August Pi Sunyer, ICII, Serv Enfermedades Infecciosas, Barcelona, Spain

来源：

AIDS | 2002年 / 16卷 / 11期

关键词：

D O I：

10.1097/00002030-200207260-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the therapeutic outcomes of all antiretroviral-naive HIV-1-infected patients with fewer than 100 CD4 cells/mul, who received efavirenz-based highly active antiretroviral therapy (HAART). Sixty-one percent suffered AIDS-defining diseases, and after a median follow-up of 45 weeks there were three deaths and five AIDS-related conditions (two relapses, three new). Efavirenz-based HAART was found to be effective in profoundly immunosuppressed HIV-1-infected patients.

引用

页码：1554 / 1556

页数：3

共 11 条

[1] Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults [J].

Bartlett, JA ;

DeMasi, R ;

Quinn, J ;

Moxham, C ;

Rousseau, F .

AIDS, 2001, 15 (11) :1369-1377

[2]

Berenguer J, 2000, Enferm Infecc Microbiol Clin, V18, P457

[3] Inflammatory reactions in HIV-1-infected persons after initiation of highly active antiretroviral therapy [J].

DeSimone, JA ;

Pomerantz, RJ ;

Babinchak, TJ .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (06) :447-454

[4] Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy - The Swiss HIV Cohort Study [J].

Friedl, AC ;

Ledergerber, B ;

Flepp, M ;

Hirschel, B ;

Telenti, A ;

Furrer, H ;

Bucher, HC ;

Bernasconi, E ;

Weber, R .

AIDS, 2001, 15 (14) :1793-1800

[5] Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy [J].

Jacobson, MA ;

Zegans, M ;

Pavan, PR ;

ODonnell, JJ ;

Sattler, F ;

Rao, N ;

Owens, S ;

Pollard, R .

LANCET, 1997, 349 (9063) :1443-1445

[6]

LEVY R, 2001, 8 C RETR OPP INF CHI

[7] High incidence of herpes zoster in patients with AIDS soon after therapy with protease inhibitors [J].

Martínez, E ;

Gatell, J ;

Morán, Y ;

Aznar, E ;

Buira, E ;

Guelar, A ;

Mallolas, J ;

Soriano, E .

CLINICAL INFECTIOUS DISEASES, 1998, 27 (06) :1510-1513

[8]

Miro J M, 2000, Enferm Infecc Microbiol Clin, V18, P329

[9] Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS [J].

Narita, M ;

Ashkin, D ;

Hollender, ES ;

Pitchenik, AE .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (01) :157-161

[10]

NELSON M, 2000, 10 EUR C CLIN MICR I

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