Protein A induced protection against experimental Candidiasis in mice

被引：11

作者：

Srivastava, AK

Singh, KP

Ray, PK

机构：

[1] IND TOXICOL RES CTR,ENVIRONM MICROBIOL DIV,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] WAYNE STATE UNIV,INST CHEM TOXICOL,DETROIT,MI 48201

来源：

MYCOPATHOLOGIA | 1997年 / 138卷 / 01期

关键词：

candidiasis; immunoprotection; protein A;

D O I：

10.1023/A:1006830620523

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus protein-A (SpA), an important multipotent immunostimulator, increased the resistance to infection with Candida albicans in Swiss albino mice. The mice treated with repeated immunologically active doses (1 mu g/mouse) of SpA, pre-and post-infection, showed one hundred percent protection against experimental candidiasis, and constituted the first such report. Protection could be demonstrated on the basis of leukocyte counts, colony forming unit (CPU) kinetics in liver, spleen, kidney and peritoneal cavity, and phagocytosis by monocyte-derived macrophages.

引用

页码：21 / 28

页数：8

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