Seroprevalence of Neutralizing Antibodies Against Dengue Virus in Two Localities in the State of Morelos, Mexico

被引：36

作者：

Amaya-Larios, Irma Y.

Arali Martinez-Vega, Ruth ^{[1
]}

Mayer, Sandra V. ^{[2
,3
,4
,5
]}

Galeana-Hernandez, Marisol

Comas-Garcia, Andreu

Sepulveda-Salinas, Karla J.

Falcon-Lezama, Jorge A.

Vasilakis, Nikos ^{[2
,3
,4
,5
]}

Ramos-Castaneda, Jose ^{[1
,4
]}

机构：

[1] Org Latinoamer Fomento Invest Salud, Bucaramanga, Stder, Colombia

[2] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

[4] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA

[5] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2014年 / 91卷 / 05期

基金：

美国国家卫生研究院;

关键词：

ORIGINAL ANTIGENIC SIN; RISK-FACTORS; HUMAN MOVEMENT; CHILDREN; TRANSMISSION; SEROTYPES; EPIDEMIC; INFECTIONS; PREVALENCE; DYNAMICS;

D O I：

10.4269/ajtmh.14-0145

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Humoral immune response against dengue virus (DENY) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.

引用

页码：1057 / 1065

页数：9

共 54 条

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