Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

被引：7

作者：

Bagby, Grover C. ^{[1
,3
,4
]}

Meyers, Gabrielle ^{[1
,2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Hematol Malignancies Program, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

[4] VA Med Ctr Portland, NW VA Canc Res Ctr, Portland, OR 97239 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Clonal evolution; Myelodysplasia; Aplastic anemia; Natural selection; Fanconi's anemia; Apoptosis; Leukemogenesis; TUMOR-NECROSIS-FACTOR; ACQUIRED APLASTIC-ANEMIA; COLONY-STIMULATING-FACTOR; STEM-CELL TRANSPLANTATION; BONE-MARROW; FANCONI-ANEMIA; FACTOR-ALPHA; TNF-ALPHA; IMMUNOSUPPRESSIVE THERAPY; CYTOGENETIC ABNORMALITIES;

D O I：

10.1016/j.hoc.2009.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

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收藏

页码：361 / +

页数：17

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