Enzymatic preparation of optically active alpha-methylene beta-lactones by lipase-catalyzed kinetic resolution through asymmetric transesterification

被引：25

作者：

Adam, W ^{[1
]}

Groer, P ^{[1
]}

SahaMoller, CR ^{[1
]}

机构：

[1] UNIV WURZBURG,INST ORGAN CHEM,D-97074 WURZBURG,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(97)00054-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The lipase-catalyzed asymmetric transesterification of racemic alpha-methylene beta-lactones 1 with benzyl alcohol in organic media afforded the optically active beta-lactones and the corresponding beta-hydroxy esters 2 in excellent enantiomeric excess (ee 95-99%). (C) 1997 Elsevier Science Ltd.

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页码：833 / 836

页数：4

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