The hedgehog pathway as a therapeutic target for treatment of breast cancer

被引：29

作者：

Barginear, M. F. ^{[1
]}

Leung, M. ^{[2
]}

Budman, D. R. ^{[2
]}

机构：

[1] Mt Sinai Sch Med, Breast Canc Med Program, Tisch Canc Inst, New York, NY 10029 USA

[2] NYU, Sch Med, N Shore Univ Hosp, Don Monti Div Oncol,Monter Canc Ctr, New York, NY USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 116卷 / 02期

关键词：

Hedgehog; Breast cancer; Cell signaling; Hedgehog inhibitors; MAMMARY-GLAND DEVELOPMENT; BASAL-CELL CARCINOMA; TUMOR STEM-CELLS; HUMAN-CHROMOSOME BANDS; IN-SITU HYBRIDIZATION; SONIC-HEDGEHOG; SIGNALING PATHWAY; SMALL-MOLECULE; SELF-RENEWAL; BETA-CATENIN;

D O I：

10.1007/s10549-009-0423-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hedgehog (Hh) signaling pathway plays a key role in a variety of processes, such as embryogenesis and maintenance of adult tissue homeostasis. It is also becoming increasingly clear that this pathway can have a crucial role in tumorigenesis. Most recently, the Hh signaling pathway has been implicated in the development and maintenance of breast cancer. Here we review Hh signaling, advances in small molecule and antibody-based inhibitors targeting the Hh pathway, and dysregulation of the Hh signaling pathway in breast cancer.

引用

页码：239 / 246

页数：8

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