Apolipoproteins and aging: emerging mechanisms

被引：105

作者：

Smith, JD ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Biochem Gen & Metab, New York, NY 10021 USA

来源：

AGEING RESEARCH REVIEWS | 2002年 / 1卷 / 03期

关键词：

apolipoprotein E; longevity; cardiovascular disease; Alzheimer's disease;

D O I：

10.1016/S1568-1637(02)00005-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the goals of modem medicine is to foster successful aging. In order to age successfully, one must accomplish two things: first, survive; and second, survive with good health and a sharp mind. In this discussion of apolipoproteins and aging, the focus will be on apolipoprotein E (apoE), a protein with three common isoforms, which has a large impact on longevity and successful aging. One variant of apoE (E4) is associated with increased risk for heart disease, stroke and Alzheimer's disease (AD). In addition, some of the potential mechanisms for the observed effects of apoE on aging will be discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：345 / 365

页数：21

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