WhichGenes: a web-based tool for gathering, building, storing and exporting gene sets with application in gene set enrichment analysis

被引:23
作者
Glez-Pena, Daniel [1 ]
Gomez-Lopez, Gonzalo [2 ]
Pisano, David G. [2 ]
Fdez-Riverola, Florentino [1 ,3 ]
机构
[1] Univ Vigo, Higher Tech Sch Comp Engn, Orense, Spain
[2] Spanish Natl Canc Res Ctr CNIO, Struct Biol & Biocomp Programme, Bioinformat Unit UBio, Madrid, Spain
[3] Univ Vigo, Dept Informat, Vigo 36310, Pontevedra, Spain
关键词
RESOURCE;
D O I
10.1093/nar/gkp263
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WhichGenes is a web-based interactive gene set building tool offering a very simple interface to extract always-updated gene lists from multiple databases and unstructured biological data sources. While the user can specify new gene sets of interest by following a simple four-step wizard, the tool is able to run several queries in parallel. Every time a new set is generated, it is automatically added to the private gene-set cart and the user is notified by an e-mail containing a direct link to the new set stored in the server. WhichGenes provides functionalities to edit, delete and rename existing sets as well as the capability of generating new ones by combining previous existing sets (intersection, union and difference operators). The user can export his sets configuring the output format and selecting among multiple gene identifiers. In addition to the user-friendly environment, WhichGenes allows programmers to access its functionalities in a programmatic way through a Representational State Transfer web service. WhichGenes front-end is freely available at http://www.whichgenes.org/, WhichGenes API is accessible at http://www.whichgenes.org/api/.
引用
收藏
页码:W329 / W334
页数:6
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