Interactions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptors

The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E(2). Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10(-5) M) did not block this short-lived enhancement. Thus, it does nor seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons. NeuroReeort 11:973-976 (C) 2000 Lippincott Williams & Wilkins.