Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer

被引:332
作者
Forrest, LM
McMillan, DC [1 ]
McArdle, CS
Angerson, WJ
Dunlop, DJ
机构
[1] Univ Glasgow, Royal Infirm, Dept Surg, Glasgow G31 2ER, Lanark, Scotland
[2] Royal Infirm, Dept Med Oncol, Glasgow G31 2ER, Lanark, Scotland
关键词
systemic inflammatory response; prognostic score; stage; performance status; survival; chemotherapy; non-small-cell lung cancer;
D O I
10.1038/sj.bjc.6601789
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
The value of an inflammation-based prognostic score (GPS) was compared with performance status (ECOG) in patients (n = 109) receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer. On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25-2.84, P = 0.002).
引用
收藏
页码:1704 / 1706
页数:3
相关论文
共 17 条
[1]
Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer [J].
Ando, M ;
Ando, Y ;
Hasegawa, Y ;
Shimokata, K ;
Minami, H ;
Wakai, K ;
Ohno, Y ;
Sakai, S .
BRITISH JOURNAL OF CANCER, 2001, 85 (11) :1634-1639
[2]
Using the modified Barthel index to estimate survival in cancer patients in hospice: observational study [J].
Bennett, M ;
Ryall, N .
BRITISH MEDICAL JOURNAL, 2000, 321 (7273) :1381-1382
[3]
Chlebowski RT, 1996, NUTRITION, V12, pS43
[4]
Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer [J].
Forrest, LM ;
McMillan, DC ;
McArdle, CS ;
Angerson, WJ ;
Dunlop, DJ .
BRITISH JOURNAL OF CANCER, 2003, 89 (06) :1028-1030
[5]
Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma [J].
Ikeda, M ;
Natsugoe, S ;
Ueno, S ;
Baba, M ;
Aikou, T .
ANNALS OF SURGERY, 2003, 238 (02) :197-202
[6]
Klastersky J, 2001, LUNG CANCER-J IASLC, V34, pS95
[7]
The role of C-reactive protein as a prognostic indicator in advanced cancer. [J].
Mahmoud F.A. ;
Rivera N.I. .
Current Oncology Reports, 2002, 4 (3) :250-255
[8]
Systemic inflammatory response predicts survival following curative resection of colorectal cancer [J].
McMillan, DC ;
Canna, K ;
McArdle, CS .
BRITISH JOURNAL OF SURGERY, 2003, 90 (02) :215-219
[9]
Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss [J].
McMillan, DC ;
Watson, WS ;
O'Gorman, P ;
Preston, T ;
Scott, HR ;
McArdle, CS .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 39 (02) :210-213
[10]
MOUNTAIN CF, 1986, CHEST, V89, pS225, DOI 10.1378/chest.89.4.225S