The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

被引：354

作者：

Budni, Josiane ^{[1
]}

Bellettini-Santos, Tatiani ^{[1
]}

Mina, Francielle ^{[1
]}

Garcez, Michelle Lima ^{[1
]}

Zugno, Alexandra Ioppi ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Neurociencias, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, Criciuma, SC, Brazil

来源：

AGING AND DISEASE | 2015年 / 6卷 / 05期

关键词：

BNDF; NGF; GDNF; Aging; Alzheimer's disease; NERVE GROWTH-FACTOR; MILD COGNITIVE IMPAIRMENT; FACTOR VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR LEVELS; HUMAN BRAIN; NORADRENERGIC INNERVATIONS; NEURONAL APOPTOSIS; CSF CONCENTRATIONS; MEMORY IMPAIRMENT; MESSENGER-RNA;

D O I：

10.14336/AD.2015.0825

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.

引用

页码：331 / 341

页数：11

共 111 条

[1]

Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis [J].

Ahmed, Anthony O. ;

Mantini, Andrew M. ;

Fridberg, Daniel J. ;

Buckley, Peter F. .

PSYCHIATRY RESEARCH, 2015, 226 (01) :1-13

[2]

Identification of Novel GDNF Isoforms and cis-Antisense GDNFOS Gene and Their Regulation in Human Middle Temporal Gyrus of Alzheimer Disease [J].

Airavaara, Mikko ;

Pletnikova, Olga ;

Doyle, Maire E. ;

Zhang, Yong E. ;

Troncoso, Juan C. ;

Liu, Qing-Rong .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (52) :45093-45102

[3]

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan [J].

Akatsu, Hiroyasu ;

Yamagata, Hidehisa D. ;

Kawamata, Jun ;

Kamino, Kouzin ;

Takeda, Masatoshi ;

Yamamoto, Takayuki ;

Miki, Tetsuro ;

Tooyama, Ikuo ;

Shimohama, Shun ;

Kosaka, Kenji .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 22 (03) :216-222

[4]

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system [J].

Al-Shawi, Raya ;

Hafner, Angela ;

Olson, Jessica ;

Chun, Soyon ;

Raza, Saba ;

Thrasivoulou, Christopher ;

Lovestone, Simon ;

Killick, Richard ;

Simons, Paul ;

Cowen, Timothy .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (08) :2103-2114

[5]

GDNF, NGF and BDNF as therapeutic options for neurodegeneration [J].

Allen, Shelley J. ;

Watson, Judy J. ;

Shoemark, Deborah K. ;

Barua, Neil U. ;

Patel, Nikunj K. .

PHARMACOLOGY & THERAPEUTICS, 2013, 138 (02) :155-175

[6]

Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) Patients are Characterized by Increased BDNF Serum Levels [J].

Angelucci, F. ;

Spalletta, G. ;

di Iulio, F. ;

Ciaramella, A. ;

Salani, F. ;

Varsi, A. E. ;

Gianni, W. ;

Sancesario, G. ;

Caltagirone, C. ;

Bossu, P. .

CURRENT ALZHEIMER RESEARCH, 2010, 7 (01) :15-20

[7]

GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo [J].

Arenas, E ;

Trupp, M ;

Akerud, P ;

Ibanez, CF .

NEURON, 1995, 15 (06) :1465-1473

[8]

Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function [J].

Ari, Csilla ;

Borysov, Sergiy I. ;

Wu, Jiashin ;

Padmanabhan, Jaya ;

Potter, Huntington .

NEUROBIOLOGY OF AGING, 2014, 35 (08) :1839-1849

[9]

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret [J].

Baloh, RH ;

Tansey, MG ;

Golden, JP ;

Creedon, DJ ;

Heuckeroth, RO ;

Keck, CL ;

Zimonjic, DB ;

Popescu, NC ;

Johnson, EM ;

Milbrandt, J .

NEURON, 1997, 18 (05) :793-802

[10]

A metabolic and functional overview of brain aging linked to neurological disorders [J].

Baquer, Najma Z. ;

Taha, Asia ;

Kumar, Pardeep ;

McLean, P. ;

Cowsik, S. M. ;

Kale, R. K. ;

Singh, R. ;

Sharma, Deepak .

BIOGERONTOLOGY, 2009, 10 (04) :377-413

← 1 2 3 4 5 6 7 8 9 10 →