Toxicogenomics; transcript profiling and potential application to chemical allergy

被引：28

作者：

Pennie, WD ^{[1
]}

Kimber, I ^{[1
]}

机构：

[1] Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England

来源：

TOXICOLOGY IN VITRO | 2002年 / 16卷 / 03期

关键词：

toxicogenomics; transcript prolifing; altered gene expression; hazard identification; allergy;

D O I：

10.1016/S0887-2333(02)00007-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Novel transcript profiling technologies allow simultaneous measurement of the changes in expression of many hundreds or many thousands of genes. The availability of these methods has brought about revolutionary changes in many areas of investigative biology, where analyses of patterns of gene expression, rather than of individual genes, are being employed. The application of these technologies to toxicology (toxicogenomics) offers new opportunities for both mechanistic toxicity research and predictive toxicology. Here we provide an overview of the basic approaches used in this field. The development of a series of toxicology-specific microarrays in our own laboratory is discussed, together with an example of one area of mechanistic research, chemical allergy, where we believe judicious application of toxicogenomics will make an important contribution. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：319 / 326

页数：8

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