Determination of oxygen extraction ratios by magnetic resonance imaging

被引：83

作者：

Oja, JME

Gillen, JS

Kauppinen, RA

Kraut, M

van Zijl, PCM

机构：

[1] Johns Hopkins Univ, Sch Med, Div MR Res, Dept Radiol, Baltimore, MD 21205 USA

[2] Univ Kuopio, NMR Res Grp, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1999年 / 19卷 / 12期

关键词：

oxygen extraction; mismatch; uncoupling; magnetic resonance imaging;

D O I：

10.1097/00004647-199912000-00001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T-2 of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.

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页码：1289 / 1295

页数：7

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