T-cell regulation: Thy-1-hiding in full view

被引:39
作者
Killeen, N
机构
关键词
D O I
10.1016/S0960-9822(06)00402-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thy-1 is a highly abundant glycoprotein on the surface of thymocytes and neurons, A null mutation in the gene encoding Thy-1 deregulates T-cell receptor signaling and causes abnormal thymocyte development; does this mean that Thy-1 has a signaling function?
引用
收藏
页码:R774 / R777
页数:4
相关论文
共 25 条
[1]  
[Anonymous], LEUKOCYTE ANTIGEN FA
[2]   MOLECULAR ASSOCIATIONS BETWEEN THE LYMPHOCYTE-T ANTIGEN RECEPTOR COMPLEX AND THE SURFACE ANTIGEN-CD2, ANTIGEN-CD4, OR ANTIGEN-CD8 AND ANTIGEN-CD5 [J].
BEYERS, AD ;
SPRUYT, LL ;
WILLIAMS, AF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2945-2949
[3]   PROTEIN LIPIDATION IN CELL SIGNALING [J].
CASEY, PJ .
SCIENCE, 1995, 268 (5208) :221-225
[4]   Co-stimulation in T cell responses [J].
Chambers, CA ;
Allison, JP .
CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (03) :396-404
[5]   Tuning antigen receptor signaling by CD22: Integrating cues from antigens and the microenvironment [J].
Cyster, JG ;
Goodnow, CC .
IMMUNITY, 1997, 6 (05) :509-517
[6]   Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5 [J].
Dennehy, KM ;
Broszeit, R ;
Garnett, D ;
Durrheim, GA ;
Spruyt, LL ;
Beyers, AD .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (03) :679-686
[7]   Thymocytes in Thy-1(-/-) mice show augmented TCR signaling and impaired differentiation [J].
Hueber, AO ;
Bernard, AM ;
LangletElBattari, C ;
Marguet, D ;
Massol, P ;
Foa, C ;
Brun, N ;
Garcia, S ;
Stewart, C ;
Pierres, M ;
He, HT .
CURRENT BIOLOGY, 1997, 7 (09) :705-708
[8]   Natural killer cell receptors [J].
Long, EO ;
Wagtmann, N .
CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (03) :344-350
[9]   PHOSPHATIDYLINOSITOL IS THE MEMBRANE-ANCHORING DOMAIN OF THE THY-1 GLYCOPROTEIN [J].
LOW, MG ;
KINCADE, PW .
NATURE, 1985, 318 (6041) :62-64
[10]  
MANJUNATH N, 1993, J IMMUNOL, V151, P1528