Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus

被引：16

作者：

Fukui, Michiaki ^{[1
]}

Shiraishi, Emi ^{[1
]}

Tanaka, Muhei ^{[1
]}

Senmaru, Takafumi ^{[1
]}

Sakabe, Kazumi ^{[1
]}

Harusato, Ichiko ^{[1
]}

Hasegawa, Goji ^{[1
]}

Nakamura, Naoto ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Endocrinol & Metab, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2009年 / 58卷 / 08期

关键词：

PLATELET-AGGREGATION; MICROALBUMINURIA; RISK; MORTALITY;

D O I：

10.1016/j.metabol.2009.03.009

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We performed an observational study to investigate if plasma 5-hydroxyindole-3-acetic acid (5-HIAA), a derivative end product of serotonin (5-hydroxytryptamine), concentration could be a predictor for deterioration of urinary albumin excretion. The relationship between baseline plasma 5-HIAA concentration and changes in urinary albumin excretion for 24 months was investigated in 162 male patients with type 2 diabetes mellitus. Patients were divided into tertiles according to plasma 5-HIAA concentration. Greater changes in urinary albumin excretion were seen in patients with high plasma 5-HIAA concentration (112.8 +/- 36.2 mg/g creatinine) than in patients with low plasma 5-HIAA concentration (7.6 +/- 8.0 mg/g creatinine, P=.0011) or in patients with intermediate plasma 5-HIAA concentration (25.6 +/- 15.0 mg/g creatinine, P=.0070) after adjustment for baseline values of urinary albumin excretion. A positive correlation was observed between log (plasma 5-HIAA concentration) and changes in urinary albumin excretion (r=0.314, P<.0001). Multiple regression analysis demonstrated that log (plasma 5-HIAA concentration) (beta = .284, P = .0013) was an independent determinant of changes in urinary albumin excretion. In conclusion, plasma 5-HIAA concentration was positively correlated with changes in urinary albumin excretion, which may indicate causality in diabetic nephropathy in male patients with type 2 diabetes mellitus and high plasma 5-HIAA concentration. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1076 / 1079

页数：4

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