Integrin αVβ5 is not involved in adeno-associated virus type 2 (AAV2) infection

被引：39

作者：

Qiu, JM ^{[1
]}

Brown, KE ^{[1
]}

机构：

[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

VIROLOGY | 1999年 / 264卷 / 02期

关键词：

D O I：

10.1006/viro.1999.0010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

alpha V beta 5 integrin was recently proposed as a coreceptor for adeno-associated virus type 2 (AAV2) infection (Summerford et al., 1999, Nat Med. 5, 78-82), based mainly on the direct binding of AAV2 to denatured beta 5 by virus overlay assay. In studies using purified natural or recombinant human integrin alpha V beta 5 we were unable to demonstrate AAV2 binding, either by virus overlay or by liquid binding assay. Furthermore, neither purified integrin alpha V beta 5, nor RGD peptides, nor functional blocking monoclonal antibody blocked rAAV2 transduction. These data strongly suggest that integrin alpha V beta 5 is not involved in AAV2 infection.

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页码：436 / 440

页数：5

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