T cell immunity in lymphoid and non-lymphoid tissues

被引：91

作者：

Lefrançois, L ^{[1
]}

Masopust, D ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Immunol, Farmington, CT 06030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(02)00360-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection, Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.

引用

页码：503 / 508

页数：6

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