Effect of aspirin on random pattern flap survival in rats

被引：12

作者：

Shalom, A ^{[1
]}

Herbert, M ^{[1
]}

Westreich, M ^{[1
]}

机构：

[1] Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel

来源：

EUROPEAN JOURNAL OF PLASTIC SURGERY | 2000年 / 23卷 / 01期

关键词：

aspiring; flaps; ischemia;

D O I：

10.1007/s002380050005

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Aspirin is known to increase dermal perfusion and is commonly used to enhance anastomotic patency in microvascular surgery. However, we were unable to find any reports of an effect of aspirin on simple flap survival. In order to determine its effect on flap survival, a controlled experiment was designed using random pattern flaps in rats. The results indicate a statistically significant increase in flap survival in rats receiving aspirin. It is suggested that aspirin's anti-aggregation effect, in combination with its vasodilatational and anti-inflammatory effect, increases the perfusion in the initial critical hours and thus secondarily decreases the reperfusion injury.

引用

页码：21 / 24

页数：4

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