TIMP3 checks inflammation

被引：68

作者：

Black, RA ^{[1
]}

机构：

[1] Amgen Inc, Seattle, WA USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 09期

关键词：

D O I：

10.1038/ng0904-934

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mice deficient in the metalloprotease inhibitor TIMP3, which inhibits the tumor-necrosis factor alpha (TNF-alpha)-converting enzyme (TACE, also called ADAM17), have elevated levels of TNF and severe inflammation in the liver. This result confirms the physiological importance of the soluble form of TNF and identifies TIMP3 as a crucial regulator of this inflammatory cytokine.

引用

页码：934 / 935

页数：3

共 16 条

[1] TNF-α converting enzyme (TACE) is inhibited by TIMP-3
Amour, A
Slocombe, PM
Webster, A
Butler, M
Knight, CG
Smith, BJ
Stephens, PE
Shelley, C
Hutton, M
Knäuper, V
Docherty, AJP
Murphy, G
[J]. FEBS LETTERS, 1998, 435 (01) : 39 - 44
[2] Metalloproteinase inhibitors: biological actions and therapeutic opportunities
Baker, AH
Edwards, DR
Murphy, G
[J]. JOURNAL OF CELL SCIENCE, 2002, 115 (19) : 3719 - 3727
[3] Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro - TIMP-3 promotes apoptosis
Baker, AH
Zaltsman, AB
George, SJ
Newby, AC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (06) : 1478 - 1487
[4] Tumor necrosis factor-α converting enzyme
Black, RA
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (01) : 1 - 5
[5] TIMPs as multifacial proteins
Lambert, E
Dassé, E
Haye, B
Petitfrère, E
[J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2004, 49 (03) : 187 - 198
[6] Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)
Leco, KJ
Waterhouse, P
Sanchez, OH
Gowing, KLM
Poole, AR
Wakeham, A
Mak, TW
Khokha, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (06) : 817 - 829
[7] Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-α-converting enzyme
Lee, MH
Verma, V
Maskos, K
Nath, D
Knäuper, V
Dodds, P
Amour, A
Murphy, G
[J]. BIOCHEMICAL JOURNAL, 2002, 364 (01) : 227 - 234
[8] Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration
Mohammed, FF
Smookler, DS
Taylor, SEM
Fingleton, B
Kassiri, Z
Sanchez, OH
English, JL
Matrisian, LM
Au, B
Yeh, WC
Khokha, R
[J]. NATURE GENETICS, 2004, 36 (09) : 969 - 977
[9] Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
Moss, ML
Jin, SLC
Milla, ME
Burkhart, W
Carter, HL
Chen, WJ
Clay, WC
Didsbury, JR
Hassler, D
Hoffman, CR
Kost, TA
Lambert, MH
Leesnitzer, MA
McCauley, P
McGeehan, G
Mitchell, J
Moyer, M
Pahel, G
Rocque, W
Overton, LK
Schoenen, F
Seaton, T
Su, JL
Warner, J
Willard, D
Becherer, JD
[J]. NATURE, 1997, 385 (6618) : 733 - 736
[10] Matrix metalloproteinases
Nagase, H
Woessner, JF
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (31) : 21491 - 21494

← 1 2 →