Serum iron and ferritin in acute neuroleptic akathisia

被引:14
作者
Hofmann, M
Seifritz, E
Botschev, C
Kräuchi, K
Müller-Spahn, F
机构
[1] Univ Basel, Dept Psychiat, CH-4025 Basel, Switzerland
[2] Univ Munich, Dept Psychiat, D-80336 Munich, Germany
关键词
extrapyramidal side effects; antipsychotics; neuroleptics; schizophrenia;
D O I
10.1016/S0165-1781(00)00115-3
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Acute akathisia is a common and disturbing side effect of classic antipsychotic medication. Some evidence suggests a role for iron deficiency in chronic and tardive akathisia. In acute akathisia, however, the data are contradictory. Serum iron and ferritin levels of 33 inpatients with acute akathisia during classic neuroleptic medication were compared with those of 23 patients on classic neuroleptics without this side effect. Akathisia was rated by means of the Hillside Akathisia Scale. The groups were balanced for age (mean 38.5 +/- 14.5), medication (butyrophenone- and phenothiazine-derived neuroleptics) and diagnosis (schizophrenia, schizoaffective disorder, psychotic affective disorder). Patients with acute akathisia had significantly lower serum ferritin levels than the patients in the control group. However, the ferritin (56.94 +/- 39.54 ng/ml) and iron (88.52 +/- 40.0 mg/dl) levels in these patients were within the normal range (ferritin 30-300 ng/dl, iron 80-180 mg/dl). No correlations between serum iron or ferritin and akathisia ratings could be found. Although some reduction in serum ferritin was found in patients with acute akathisia compared to patients without akathisia, the difference was small and the ferritin levels were within the range of the normal population. These findings suggest a minor role for iron deficiency in acute akathisia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:201 / 207
页数:7
相关论文
共 27 条
[1]  
BARCLAY CL, 1992, MOVEMENT DISORD, V3, P296
[2]   RELATIONSHIP BETWEEN IRON STATUS AND CHRONIC AKATHISIA IN AN INPATIENT POPULATION WITH CHRONIC-SCHIZOPHRENIA [J].
BARNES, TRE ;
HALSTEAD, SM ;
LITTLE, PWA .
BRITISH JOURNAL OF PSYCHIATRY, 1992, 161 :791-796
[3]   LOW PLASMA IRON STATUS AND AKATHISIA [J].
BARTON, A ;
BOWIE, J ;
EBMEIER, K .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (08) :671-674
[4]   CLINICAL CHARACTERISTICS OF AKATHISIA - A SYSTEMATIC INVESTIGATION OF ACUTE PSYCHIATRIC INPATIENT ADMISSIONS [J].
BRAUDE, WM ;
BARNES, TRE ;
GORE, SM .
BRITISH JOURNAL OF PSYCHIATRY, 1983, 143 (AUG) :139-150
[5]  
BROWN KW, 1987, LANCET, V1, P1234
[6]  
FLEISCHHACKER WW, 1989, PSYCHOPHARMACOL BULL, V25, P222
[7]   THE HILLSIDE AKATHISIA SCALE - A RELIABILITY COMPARISON OF THE ENGLISH AND GERMAN VERSIONS [J].
FLEISCHHACKER, WW ;
MILLER, CH ;
SCHETT, P ;
BARNAS, C ;
EHRMANN, H .
PSYCHOPHARMACOLOGY, 1991, 105 (01) :141-144
[8]   AKATHISIA, PORPHYRIA AND LOW IRON [J].
FORNAZZARI, L ;
REMINGTON, G .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1991, 36 (07) :548-548
[9]  
GELENBERG AJ, 1983, PRACTITIONERS GUIDE, P124
[10]  
GOLD R, 1995, J CLIN PSYCHIAT, V56, P476