Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion

被引：112

作者：

de Haan, CAM

Stadler, K

Godeke, GJ

Bosch, BJ

Rottier, PJM

机构：

[1] Univ Utrecht, Fac Vet Med, Div Virol, Dept Infect Dis & Immunol, NL-3584 CL Utrecht, Netherlands

[2] Univ Utrecht, Biomembrane Inst, NL-3584 CL Utrecht, Netherlands

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 11期

关键词：

D O I：

10.1128/JVI.78.11.6048-6054.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cleavage of the mouse hepatitis coronavirus strain A59 spike protein was blocked in a concentration-dependent manner by a peptide furin inhibitor, indicating that furin or a furin-like enzyme is responsible for this process. While cell-cell fusion was clearly affected by preventing spike protein cleavage, virus-cell fusion was not, indicating that these events have different requirements.

引用

收藏

页码：6048 / 6054

页数：7

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