Staged informed consent for a randomized clinical trial in childhood leukemia: Impact on the consent process

被引:37
作者
Angiolillo, AL
Simon, C
Kodish, E
Lange, B
Noll, RB
Ruccione, K
Matloub, Y
机构
[1] Childrens Natl Med Ctr, Div Hematol Oncol, Washington, DC 20010 USA
[2] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Sch Med,Univ Hosp Cleveland, Dept Pediat,Rainbow Ctr Pediat Eth, Cleveland, OH 44106 USA
[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
[4] Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA
[5] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
[6] Univ Wisconsin, Dept Pediat, Madison, WI USA
关键词
children; consent; leukemia;
D O I
10.1002/pbc.20010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Children Cancer Group (CCG) 1991 is the first childhood acute lymphoblastic leukemia trial within CCG that allowed the utilization of a staged approach to the consent process. Methods. One hundred and forty subjects participated in the Project on Informed Consent which compared the primary outcome measures in the consent process of patients enrolled in CCG-1991 with those enrolled in other CCG leukemia studies. Results. The parents' trust scores were higher for the CCG-1991 compared with other protocols. Eighty percent of parents enrolled in CCG-1991 understood the distinction between the randomized clinical trial and the standard treatment arm, compared with 62.5% in the other studies, P=0.05. Multiple other outcome measures suggested a positive impact from staged informed consent. Conclusions. Our results suggest that a consent process with a staged approach can help investigators obtain a more truly informed consent. Future research is needed to confirm the benefits of the staged approach to the informed consent process.
引用
收藏
页码:433 / 437
页数:5
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