The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression

被引：52

作者：

Gupta, AK

Ruvolo, V

Patterson, C

Swaminathan, S

机构：

[1] Univ Texas, Med Branch, Sealy Ctr Oncol & Hematol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Sealy Ctr Mol Cardiol, Galveston, TX 77555 USA

[3] Univ Texas, Med Branch, Dept Internal Med, Div Infect Dis, Galveston, TX 77555 USA

[4] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 02期

关键词：

D O I：

10.1128/JVI.74.2.1038-1044.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Homologs of the Epstein-Barr virus (EBV) SM protein exist in several human and nonhuman herpesviruses. Structure and function differ significantly among these proteins. We have cloned and characterized the human herpesvirus 8 (HHV8) gene, KS-SM, which is homologous to the EBV SM and herpes simplex virus ICP27 genes, from an HHV8-infected primary effusion lymphoma. KS SM is shown to be a posttranscriptional activator of gene expression in cotransfection studies. KS-SM activated gene expression in a gene-specific, promoter-independent manner. In particular, KS-SM enhanced the expression of KDR/flk-1, a receptor fbr vascular endothelial growth factor (VEGF), in cotransfection studies. Since expression of KDR/flk-1 is increased in Kaposi's sarcoma and HHV8 infected cell cultures and VEGF enhances the proliferation of HHV8-infected cells, KS-SM may play a pathogenic role in Kaposi's sarcoma.

引用

页码：1038 / 1044

页数：7

共 59 条

[1] Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression [J].