Formation of dTDP-rhamnose is essential for growth of mycobacteria

被引：64

作者：

Ma, YF ^{[1
]}

Pan, F ^{[1
]}

McNeil, M ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 12期

关键词：

D O I：

10.1128/JB.184.12.3392-3395.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

引用

页码：3392 / 3395

页数：4

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