Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation

被引：7

作者：

Bowie, Andrew G. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 06期

关键词：

INTRACELLULAR DNA; SENSOR;

D O I：

10.1038/ni.2894

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The DNA-damage sensor Rad50 couples the sensing of cytosolic DNA to the innate immunological adaptor CARD9 to stimulate DNA-dependent activation of the transcription factor NF-kappa B. This facilitates DNA virus stimulated production of the cytokine IL-1 beta.

引用

页码：534 / 536

页数：3

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