Evolution of a signalling system that incorporates both redundancy and diversity:: Arabidopsis SUMOylation

被引:51
作者
Chosed, Renee
Mukherjee, Sohini
Lois, Luisa Maria
Orth, Kim
机构
[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[2] Univ Barcelona, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain
关键词
Arabidopsis thaliana; reversible post-translational modification; signalling system; small ubiquitin-related modifier (SUMO); SUMOylation; ubiquitin-like protein protease-1 (ULP 1);
D O I
10.1042/BJ20060426
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The reversible post-translational modifier, SUMO (small ubiquitin-related modifier), modulates the activity of a diverse set of target proteins, resulting in important consequences to the cellular machinery. Conjugation machinery charges the processed SUMO so that it can be linked via an isopeptide bond to a target protein. The removal of SUMO moieties from conjugated proteins by isopeptidases regenerates pools of processed SUMOs and unmodified target proteins. The evolutionarily conserved SUMO-conjugating proteins, E1 and E2, recognize a diverse set of Arabidopsis SUMO proteins using them to modify protein substrates. In contrast, the deSUMOylating enzymes differentially recognize the Arabidopsis SUMO proteins, resulting in specificity of the deconjugating machinery. The specificity of the Arabidopsis deSUMOylating enzymes is further diversified by the addition of regulatory domains. Therefore the SUMO proteins, in this signalling system, have evolved to contain in formation that allows not only redundancy with the conjugation system but also diversity with the deconjugating enzymes.
引用
收藏
页码:521 / 529
页数:9
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