cis-regulatory control circuits in development

被引：90

作者：

Howard, ML ^{[1
]}

Davidson, EH ^{[1
]}

机构：

[1] CALTECH, Div Biol 15629, Pasadena, CA 91125 USA

来源：

DEVELOPMENTAL BIOLOGY | 2004年 / 271卷 / 01期

关键词：

cis-regulatory module; gene regulatory network; repression; feedback loop;

D O I：

10.1016/j.ydbio.2004.03.031

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During development, an organism undergoes many rounds of pattern formation, generating ever-greater complexity with each ensuing round of cell division and specification. The instructions for executing this process are encoded. in the cis-regulatory modules that direct the expression of developmental transcription factors and signaling molecules. Each transcription factor binding site within a cis-regulatory module contributes information about when, where, or how much a gene is turned on, and by dissecting the modules driving a given gene, all the inputs governing expression of the gene can be accurately identified. Furthermore, by mapping the output of each gene to the inputs of other genes, it is possible to reverse engineer developmental circuits and even whole networks. At this higher level of organization, common bilaterian strategies for specifying progenitor fields, locking down regulatory states, and driving development forward emerge. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：109 / 118

页数：10

共 42 条

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