PGC-1α gene and physical activity in type 2 diabetes mellitus

被引：11

作者：

Franks, Paul W. ^{[1
]}

Loos, Ruth J. F.

机构：

[1] Umea Univ Hosp, Genet Epidemiol & Clin Res Grp, Inst Publ Hlth & Clin Med, S-90185 Umea, Sweden

[2] MRC, Epidemiol Unit, Genet Grp, Cambridge, England

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2006年 / 34卷 / 04期

基金：

英国医学研究理事会;

关键词：

PGC-1; alpha; PPARGCIA; gene-lifestyle interaction type 2 diabetes;

D O I：

10.1249/01.jes.0000240021.92254.23

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Exercise stimulates PGC-1 alpha gene expression and increases VO(2)max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1 alpha mRNA and nucleotide sequence variation at PGC-1 alpha associate with lower level Of VO(2)max and increased diabetes risk. Thus PGC-1 alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.

引用

收藏

页码：171 / 175

页数：5

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