Development and validation of a reversed-phase LC method for analysing potentially counterfeit antimalarial medicines

被引：30

作者：

Gaudiano, Maria Cristina ^{[1
]}

Antoniella, Eleonora ^{[1
]}

Bertocchi, Paola ^{[1
]}

Valvo, Luisa ^{[1
]}

机构：

[1] Ist Super Sanita, Dipartimento Farmaco, I-00161 Rome, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2006年 / 42卷 / 01期

关键词：

antimalarials; counterfeit drugs; sub-standard drugs; reversed-phase liquid chromatography; screening analysis;

D O I：

10.1016/j.jpba.2006.01.059

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Pharmaceutical counterfeiting is more and more a public health problem, especially in developing countries where the most counterfeit drugs are antibiotics, antimalarials and other life-saving drugs. The evaluation of the phenomenon extent is of great concern to the World Health Organization for carrying out a global strategy to combat the phenomenon. To this purpose, a reversed-phase liquid chromatographic method to perform the separation and simultaneous determination of three different kinds of antimalarial drugs (chloroquine, quinine and mefloquine) was developed. The method was validated by using both commercial and in-laboratory produced tablets and was then verified on various in-laboratory produced formulations differing in excipient composition. Finally, the method was successfully applied to the analysis of medicinal samples purchased from the informal market in Congo, Burundi and Angola. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：132 / 135

页数：4

共 10 条

[1] QUALITY OF CHLOROQUINE PREPARATIONS MARKETED IN DAR-ES-SALAAM, TANZANIA
ABDI, YA
RIMOY, G
ERICSSON, O
ALM, C
MASSELE, AY
[J]. LANCET, 1995, 346 (8983): : 1161 - 1161
[2] *EMEA, 1996, 3AQ13A EMEA
[3] WHO steps up campaign on counterfeit drugs
Frankish, H
[J]. LANCET, 2003, 362 (9397) : 1730 - 1730
[4] A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate
Green, MD
Mount, DL
Wirtz, RA
White, NJ
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 24 (01) : 65 - 70
[5] Counterfeit drug problem "underestimated", says conference
Kapp, C
[J]. LANCET, 2002, 360 (9339) : 1080 - 1080
[6] Fake artesunate in southeast Asia
Newton, P
Proux, S
Green, M
Smithuis, F
Rozendaal, J
Prakongpan, S
Chotivanich, K
Mayxay, M
Looareesuwan, S
Farrar, L
Nosten, F
White, NJ
[J]. LANCET, 2001, 357 (9272) : 1948 - 1950
[7] QUALITY OF ANTIMALARIAL-DRUGS AND RESISTANCE TO PLASMODIUM-VIVAX IN AMAZONIAN REGION
PETRALANDA, I
[J]. LANCET, 1995, 345 (8962): : 1433 - 1433
[8] Assessment of the incidence of substandard drugs in developing countries
Shakoor, O
Taylor, RB
Behrens, RH
[J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 1997, 2 (09) : 839 - 845
[9] DRUG QUALITY, A CONTRIBUTOR TO DRUG-RESISTANCE
TAYLOR, RB
SHAKOOR, O
BEHRENS, RH
[J]. LANCET, 1995, 346 (8967): : 122 - 122
[10] *WHO, 1999, WHOEDMQSM991

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