Facilitated phospholipid flip-flop using synthetic steroid-derived translocases

被引：47

作者：

Lambert, TN

Boon, JM

Smith, BD

Pérez-Payán, MN

Davis, AP ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[2] Univ Notre Dame, Walther Canc Res Ctr, Notre Dame, IN 46556 USA

[3] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[4] Univ Dublin Trinity Coll, Dept Chem, Dublin BS8 1TS, Ireland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 19期

关键词：

D O I：

10.1021/ja026022y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cholate esters with phenylurea groups at the 7α- and 12α-positions are highly effective promoters of phosphatidylcholine translocation across vesicle and cell membranes. The urea groups are essential for strong binding of the highly polar phosphate portion of the phosphocholine headgroup and apparently cannot be replaced by simple amide, alcohol, or amine moieties. NMR and UV studies show that these synthetic translocases have very weak affinity for phosphatidylethanolamine and phosphatidylserine. Copyright © 2002 American Chemical Society.

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页码：5276 / 5277

页数：2

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