Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

被引：77

作者：

Hong, GY

Baudhuin, LM

Xu, Y

机构：

[1] Cleveland Clin Fdn, Dept Canc Biol, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Obstet & Gynecol, Cleveland, OH 44195 USA

[3] Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA

来源：

FEBS LETTERS | 1999年 / 460卷 / 03期

关键词：

sphinyosine-1-phosphate (SIP); lysophosphatidic acid (LPA); ovarian cancer; cell adhesion; aggregation;

D O I：

10.1016/S0014-5793(99)01400-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-mu M to mu M concentrations of SIP in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. SIP (10 mu M) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 mu M also induced calcium-dependent cell-cell aggregation. (C) 1999 Federation of European Biochemical Societies.

引用

页码：513 / 518

页数：6

共 23 条

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