A model for the effect on health of repeated exposure to ozone

被引:16
作者
Freijer, JI [1 ]
van Eijkeren, JCH [1 ]
van Bree, L [1 ]
机构
[1] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands
关键词
toxico-dynamic modeling; epithelial cell repair; air pollution; lung function decrement; FEV1;
D O I
10.1016/S1364-8152(02)00021-X
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Exposure to ambient ozone can result in lung function decrement in humans. Clinical studies in which humans were repeatedly exposed to ozone have revealed that lung function decrement decreases after each additional exposure event. Ozone concentrations in the ambient atmosphere show strong seasonal, episodic, and diurnal fluctuations. Accordingly, in quantitative risk analysis a model is needed, which accounts for the time dependence of the lung function decrement on observed exposure patterns. This paper presents a toxico-dynamic model predicting lung function and cellular injury and repair over time. Any ozone exposure pattern can be used as an input to the model, to predict the development of lung function decrement in time. The model incorporates the biological mechanisms generally believed to play a role in the lung function decrement due to ozone exposure. A comparison was made of the model's predictions and observed lung function decrements in seven different clinical studies. This type of ozone effect modelling and its further progress may contribute to risk evaluation and assessment of ambient exposures. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:553 / 562
页数:10
相关论文
共 39 条
[1]   A COMPARISON OF TERMINAL AIRWAY REMODELING IN CHRONIC DAILY VERSUS EPISODIC OZONE EXPOSURE [J].
BARR, BC ;
HYDE, DM ;
PLOPPER, CG ;
DUNGWORTH, DL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 106 (03) :384-407
[2]   ADAPTATION BY OLDER INDIVIDUALS REPEATEDLY EXPOSED TO 0.45 PARTS PER MILLION OZONE FOR 2 HOURS [J].
BEDI, JF ;
HORVATH, SM ;
DRECHSLERPARKS, DM .
JAPCA-THE JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION, 1989, 39 (02) :194-199
[3]   EPITHELIAL INJURY AND INTERSTITIAL FIBROSIS IN THE PROXIMAL ALVEOLAR REGIONS OF RATS CHRONICALLY EXPOSED TO A SIMULATED PATTERN OF URBAN AMBIENT OZONE [J].
CHANG, LY ;
HUANG, Y ;
STOCKSTILL, BL ;
GRAHAM, JA ;
GROSE, EC ;
MENACHE, MG ;
MILLER, FJ ;
COSTA, DL ;
CRAPO, JD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 115 (02) :241-252
[4]   Ozone-induced inflammation is attenuated with multiday exposure [J].
Christian, DL ;
Chen, LL ;
Scannell, CH ;
Ferrando, RE ;
Welch, BS ;
Balmes, JR .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (02) :532-537
[5]  
Devlin RB, 1997, INHAL TOXICOL, V9, P211
[6]   Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: A comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure [J].
Devlin, RB ;
McDonnell, WF ;
Becker, S ;
Madden, MC ;
McGee, MP ;
Perez, R ;
Hatch, G ;
House, DE ;
Koren, HS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1996, 138 (01) :176-185
[7]   OZONE-INDUCED RELEASE OF CYTOKINES AND FIBRONECTIN BY ALVEOLAR MACROPHAGES AND AIRWAY EPITHELIAL-CELLS [J].
DEVLIN, RB ;
MCKINNON, KP ;
NOAH, T ;
BECKER, S ;
KOREN, HS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (06) :L612-L619
[8]   EXPOSURE OF HUMANS TO AMBIENT LEVELS OF OZONE FOR 6.6 HOURS CAUSES CELLULAR AND BIOCHEMICAL-CHANGES IN THE LUNG [J].
DEVLIN, RB ;
MCDONNELL, WF ;
MANN, R ;
BECKER, S ;
HOUSE, DE ;
SCHREINEMACHERS, D ;
KOREN, HS .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1991, 4 (01) :72-81
[9]   MORPHOLOGICAL BASIS OF TOLERANCE TO OZONE [J].
EVANS, MJ ;
DEKKER, NP ;
CABRALANDERSON, LJ ;
SHAMI, SG .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1985, 42 (03) :366-376
[10]  
FARRELL BP, 1979, AM REV RESPIR DIS, V119, P725