Burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease

被引：362

作者：

Lacey, Charles J. N. ^{[1
]}

Lowndes, Catherine M.

Shah, Keerti V.

机构：

[1] Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, England

[2] Hlth Protect Agcy, Ctr Infect, London, England

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol, Baltimore, MD USA

来源：

VACCINE | 2006年 / 24卷

关键词：

HPV-6/11; management; non-cancerous;

D O I：

10.1016/j.vaccine.2006.06.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human Papillomavirus (HPV)-6 and -11 are the causative agents of ano-genital warts (GWs) and recurrent respiratory papillomatosis (RRP). They are low-risk HPV types that are uncommonly found in malignant lesions. GWs are an extremely prevalent sexually transmitted disease, whereas RRP is a rare disease that can be life threatening and requires multiple surgical procedures. GWs and RRP cause substantial healthcare costs. A quadrivalent HPV-6/11/16/18 vaccine (Merck/SPMSD) has shown essentially 100% protection against GWs in women in early studies. Cost-effectiveness analyses are needed to assess the benefits of the HPV-6/11 virus-like particle (VLP) components of the quadrivalent vaccine in population-based vaccination programmes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：35 / 41

页数：7

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