Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

被引：6

作者：

Haut, PR

Gonzalez-Ryan, L

Wang, LJ

Olszewski, M

Morgan, E

Kletzel, M

机构：

[1] Northwestern Univ, Sch Med, Childrens Mem Hosp, Dept Pediat,Div Hematol Oncol, Chicago, IL USA

[2] Childrens Healthcare Atlanta, Div Hematol Oncol, Atlanta, GA USA

[3] Northwestern Univ, Childrens Mem Hosp, Sch Med, Dept Pediat,Div Gastroenterol, Chicago, IL 60614 USA

来源：

PEDIATRIC TRANSPLANTATION | 2002年 / 6卷 / 04期

关键词：

cord blood; graft versus leukemia; GvHD;

D O I：

10.1034/j.1399-3046.2002.00215.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

引用

收藏

页码：348 / 351

页数：4

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