The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

被引：1522

作者：

Shackelford, David B. ^{[1
]}

Shaw, Reuben J. ^{[1
,2
]}

机构：

[1] Dulbecco Ctr Canc Res, Mol & Cell Biol Lab, Salk Inst Biol Studies, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; TUBEROUS SCLEROSIS COMPLEX; CREB COACTIVATOR TORC2; COA-CARBOXYLASE-ALPHA; FATTY-ACID SYNTHASE; CELL POLARITY; MAMMALIAN TARGET; REGULATED PHOSPHORYLATION; GLUCOSE-METABOLISM; UPSTREAM KINASE;

D O I：

10.1038/nrc2676

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissue. This function has made AMPK a key therapeutic target in patients with diabetes. The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer.

引用

页码：563 / 575

页数：13

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