Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

被引：38

作者：

Woods, YL ^{[1
]}

Rena, G ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

AKT; CKI; dual-specificity tyrosine-phosphorylated and -regulated kinase (DYRK); forkhead; nuclear exclusion;

D O I：

10.1042/bst0300391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. Recent findings demonstrate that the transcription factors FKHR (forkhead in rhabdomyosarcoma), AFX (ALL1 fused gene from chromosome X) and FKHRL1 (FKHR-like 1; termed FKHR isoforms) are phosphorylated by PKB in cells, leading to their exit from the nucleus. These exciting results suggest that FKHR isoforms may be critical effectors of PI 3-kinase/PDK1/PKB signalling in vivo.

引用

页码：391 / 397

页数：7

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