High prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium

被引:710
作者
Daly, Adrian F. [1 ]
Rixhon, Martine [1 ]
Adam, Christelle [1 ]
Dempegioti, Anastasia [1 ]
Tichomirowa, Maria A. [1 ]
Beckers, Albert [1 ]
机构
[1] Univ Liege, Dept Endocrinol, CHU Liege, B-4000 Liege, Belgium
关键词
D O I
10.1210/jc.2006-1668
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liege, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liege were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (+/- SD) prevalence was 94 +/- 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing's disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5-5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas.
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页码:4769 / 4775
页数:7
相关论文
共 18 条
[1]   Pituitary tumors: pathophysiology, clinical manifestations and management [J].
Arafah, BM ;
Nasrallah, MP .
ENDOCRINE-RELATED CANCER, 2001, 8 (04) :287-305
[2]  
*CANC SOC FINL, FINN CANC REG CANC F
[3]  
*CBTRUS, 2005 STAT REP PRIM B
[4]  
Centers for Disease Control and Prevention. Data Collection of Primary Central Nervous System Tumors, 2004, DAT COLL PRIM CENTR
[5]  
CICARELLI A, 2005, PITUITARY, V8, P3
[6]   Clinical characterization of familial isolated pituitary adenomas [J].
Daly, A. F. ;
Jaffrain-Rea, M. -L. ;
Ciccarelli, A. ;
Valdes-Socin, H. ;
Rohmer, V. ;
Tamburrano, G. ;
Borson-Chazot, C. ;
Estour, B. ;
Ciccarelli, E. ;
Brue, T. ;
Ferolla, P. ;
Emy, P. ;
Colao, A. ;
De Menis, E. ;
Lecomte, P. ;
Penfornis, F. ;
Delemer, B. ;
Bertherat, J. ;
Wemeau, J. L. ;
De Herder, W. ;
Archambeaud, F. ;
Stevenaert, A. ;
Calender, A. ;
Murat, A. ;
Cavagnini, F. ;
Beckers, A. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) :3316-3323
[7]   Clinical and genetic features of familial pituitary adenomas [J].
Daly, AF ;
Jaffrain-Rea, ML ;
Beckers, A .
HORMONE AND METABOLIC RESEARCH, 2005, 37 (06) :347-354
[8]  
Davis FG, 1999, NEUROIMAG CLIN N AM, V9, P581
[9]  
Davis FG, 2001, NEURO-ONCOLOGY, V3, P152, DOI 10.1093/neuonc/3.3.152
[10]   Pituitary tumours [J].
Davis, JRE ;
Farrell, WE ;
Clayton, RN .
REPRODUCTION, 2001, 121 (03) :363-371