Modification of polyethersulfone membrane by grafting bovine serum albumin on the surface of polyethersulfone/poly(acrylonitrile-co-acrylic acid) blended membrane

被引：146

作者：

Fang, Baohong ^{[1
]}

Ling, Qiyao ^{[1
]}

Zhao, Weifeng ^{[1
]}

Ma, Yunli ^{[1
]}

Bai, Pengli ^{[1
]}

Wei, Qiang ^{[1
]}

Li, Haifeng ^{[1
]}

Zhao, Changsheng ^{[1
]}

机构：

[1] Sichuan Univ, State Key Lab Polymer Mat Engn, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China

来源：

JOURNAL OF MEMBRANE SCIENCE | 2009年 / 329卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Polyethersulfone membrane; Surface modification; Poly(acrylonitrile-co-acrylic acid); Protein adsorption; Platelet adhesion; SULFONE) ULTRAFILTRATION MEMBRANES; PROTEIN-ADSORPTION; MICROPOROUS MEMBRANES; PLATELET-ADHESION; PHASE-SEPARATION; POLYMERIZATION; PERMEATION; BEHAVIOR; BINDING; RESISTANCE;

D O I：

10.1016/j.memsci.2008.12.008

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Polyethersulfone (PES) membrane was modified by blending with a copolymer of acrylonitrile (AN) and acrylic acid (AA), followed by grafting bovine serum albumin (BSA) onto the surface of the membrane. The PES and PAN-AA blending membranes were prepared through spin coating coupled with a liquid-liquid phase separation technique. The Micro BCA (TM) protein assay, XPS and FTIR/ATR analysis confirmed that BSA was successfully grafted onto the surface of the membranes. The pre-activated carboxyl groups of the copolymer and the amino groups of the protein contributed to the formation of BSA-PES membrane conjugates. The water contact angle, protein adsorption and platelet adhesion were obviously decreased after grafting BSA onto the membrane surface, meanwhile the water flux of the membrane was significantly increased. All these results indicated that the hydrophilicity and blood compatibility of the modified PES membranes were improved. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：46 / 55

页数：10

共 61 条

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