Efficacy of Etravirine for Treatment of Acute HIV Meningoencephalitis

被引：4

作者：

Couzigou, Carine ^{[1
,4
]}

Seang, Sophie ^{[1
,4
]}

Morand-Joubert, Laurence ^{[3
]}

Roque-Afonso, Anne-Marie ^{[2
,4
]}

Escaut, Lelia ^{[1
,4
]}

Vittecoq, Daniel ^{[1
,4
]}

机构：

[1] Hop Paul Brousse, Serv Malad Infect & Trop, AP HP, F-94804 Villejuif, France

[2] Hop Paul Brousse, Serv Virol, AP HP, F-94804 Villejuif, France

[3] Ctr Hosp Univ St Antoine, Serv Bacteriol Virol, AP HP, Paris, France

[4] Univ Paris 11, Orsay, France

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 48卷 / 06期

关键词：

CENTRAL-NERVOUS-SYSTEM; EXPERIENCED HIV-1-INFECTED PATIENTS; PLACEBO-CONTROLLED TRIAL; CEREBROSPINAL-FLUID; ANTIRETROVIRAL DRUGS; TMC125; ETRAVIRINE; DOUBLE-BLIND; RESISTANCE; SAFETY; CNS;

D O I：

10.1086/597109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a patient with human immunodeficiency virus (HIV) and hepatitis C virus coinfection who experienced recurrent episodes of acute HIV meningoencephalitis. The addition of etravirine to the therapeutic regimen completely resolved symptoms, and HIV was no longer detected in cerebrospinal spinal fluid specimens. Etravirine has a satisfactory safety profile and, in this case, was a durable alternative therapy for HIV meningoencephalitis.

引用

页码：e62 / E65

页数：4

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