Invasive Hemodynamic Characterization of Heart Failure with Preserved Ejection Fraction

被引：30

作者：

Andersen, Mads J. ^{[1
,2
]}

Borlaug, Barry A. ^{[1
]}

机构：

[1] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USA

[2] Aarhus Univ Hosp, Dept Cardiol, DK-8200 Aarhus N, Denmark

来源：

HEART FAILURE CLINICS | 2014年 / 10卷 / 03期

关键词：

Invasive hemodynamic assessment; Heart failure with preserved ejection fraction; Dyspnea; VENTRICULAR DIASTOLIC DYSFUNCTION; PULMONARY ARTERIAL-HYPERTENSION; CARDIAC STRUCTURE; SYSTOLIC FUNCTION; EXERCISE; PREVALENCE; RELAXATION; DIAGNOSIS; PRESSURE; CONTRACTILITY;

D O I：

10.1016/j.hfc.2014.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent hemodynamic studies have advanced our understanding of heart failure with preserved ejection fraction (HFpEF). Despite improved pathophysiologic insight, clinical trials have failed to identify an effective treatment for HFpEF. Invasive hemodynamic assessment can diagnose or exclude HFpEF, making it invaluable in understanding the basis of the disease. This article reviews the hemodynamic mechanisms underlying HFpEF and how they manifest clinically, discusses invasive hemodynamic assessment as a diagnostic tool, and explores how invasive hemodynamic profiling may allow understanding of pathophysiological differences and inform the design and entry criteria for future trials.

引用

页码：435 / +

页数：11

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