Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor

被引：44

作者：

Pilon, AA

Lum, JJ

Sanchez-Dardon, J

Phenix, BN

Douglas, R

Badley, AD

机构：

[1] Ottawa Hlth Res Inst, HIV Res Lab, Ottawa, ON K1H 8L6, Canada

[2] Mayo Clin, Dept Med, Div Infect Dis, Rochester, MN 55905 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2687-2691.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-de pendent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

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页码：2687 / 2691

页数：5

相关论文

共 21 条

[1] Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells [J].

Alam, A ;

Cohen, LY ;

Aouad, S ;

Sékaly, RP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (12) :1879-1890

[2] Risks and benefits of replacing protease inhibitors by nevirapine in HIV-infected subjects under long-term successful triple combination therapy [J].

Barreiro, P ;

Soriano, V ;

Blanco, F ;

Casimiro, C ;

de la Cruz, JJ ;

González-Lahoz, J .

AIDS, 2000, 14 (07) :807-812

[3] CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4+ T cells [J].

Berndt, C ;

Möpps, B ;

Angermüller, S ;

Gierschik, P ;

Krammer, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12556-12561

[4] Apoptosis - Mitochondria - the death signal integrators [J].

Brenner, C ;

Kroemer, G .

SCIENCE, 2000, 289 (5482) :1150-1151

[5] CYTOCHROME-C-OXIDASE REACTION IMPROVES HISTOPATHOLOGICAL ASSESSMENT OF ZIDOVUDINE MYOPATHY [J].

CHARIOT, P ;

MONNET, I ;

GHERARDI, R .

ANNALS OF NEUROLOGY, 1993, 34 (04) :561-565

[6] Simplification with abacavir-based triple nucleoside therapy versus continued protease inhibitor-based highly active antiretroviral therapy in HIV-1-infected patients with undetectable plasma HIV-1 RNA [J].

Clumeck, N ;

Goebel, F ;

Rozenbaum, W ;

Gerstoft, J ;

Staszewski, S ;

Montaner, J ;

Johnson, M ;

Gazzard, B ;

Stone, C ;

Athisegaran, R ;

Moore, S .

AIDS, 2001, 15 (12) :1517-1526

[7] MITOCHONDRIAL MYOPATHY CAUSED BY LONG-TERM ZIDOVUDINE THERAPY [J].

DALAKAS, MC ;

ILLA, I ;

PEZESHKPOUR, GH ;

LAUKAITIS, JP ;

COHEN, B ;

GRIFFIN, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (16) :1098-1105

[8] MECHANISM OF INHIBITION OF HIV-1 REVERSE-TRANSCRIPTASE BY NONNUCLEOSIDE INHIBITORS [J].

ESNOUF, R ;

REN, JS ;

ROSS, C ;

JONES, Y ;

STAMMERS, D ;

STUART, D .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (04) :303-308

[9] 3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine [J].

Gulick, RM ;

Mellors, JW ;

Havlir, D ;

Eron, JJ ;

Meibohm, A ;

Condra, JH ;

Valentine, FT ;

McMahon, D ;

Gonzalez, C ;

Jonas, L ;

Emini, EA ;

Chodakewitz, JA ;

Isaacs, R ;

Richman, DD .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (01) :35-39

[10] Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein R and Bcl-2 [J].

Jacotot, E ;

Ferri, KF ;

El Hamel, C ;

Brenner, C ;

Druillennec, S ;

Hoebeke, J ;

Rustin, P ;

Métivier, D ;

Lenoir, C ;

Geuskens, M ;

Vieira, HLA ;

Loeffler, M ;

Belzacq, AS ;

Briand, JP ;

Zamzami, N ;

Edelman, L ;

Xie, ZH ;

Reed, JC ;

Roques, BP ;

Kroemer, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (04) :509-519