BCG vaccine effectiveness against Buruli ulcer: A case-control study in Benin

被引：40

作者：

Nackers, Fabienne

Dramaix, Michele

Johnson, Roch Christian

Zinsou, Claude

Robert, Annie

Bakedano, Elisa de Biurrun

Glynn, Judith R.

Portaels, Francoise

Tonglet, Rene

机构：

[1] Univ Catholique Louvain, Ecole Sante Publ, Unite Epidemiol, B-1200 Brussels, Belgium

[2] Univ Catholique Louvain, Lab Stat Med, B-1200 Brussels, Belgium

[3] Programme Natl Lutte Contre Ulcere Buruli, Cotonou, Benin

[4] Ctr Depistage & Traitement Ulcere Buruli, Lalo, Benin

[5] Ctr Sanit & Nutr Gbemoten, Zagnanado, Benin

[6] Univ London London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, London WC1E 7HT, England

[7] Inst Trop Med, Dept Microbiol, B-2000 Antwerp, Belgium

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 75卷 / 04期

关键词：

D O I：

10.4269/ajtmh.2006.75.768

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

BCG remains the only possible prophylactic intervention against Buruli ulcer (BU). Estimating its public health impact on BU control is an important issue. We conducted a case-control study to investigate the vaccine effectiveness of routine BCG vaccine against BU in southern Benin. From August 2002 to August 2003, BCG vaccination status was obtained for 279 clinically diagnosed BU cases and 988 age- and sex-matched neighborhood controls. BCG coverage, which was estimated by the presence of a scar or a vaccination record, was 64.5% in cases and 67.2% in controls. There was no evidence of a protective effect of routine BCG vaccination against BU in southern Benin (vaccine effectiveness adjusted for socioeconomic status = 12%, 95% confidence interval = -24% to 37%).

引用

页码：768 / 774

页数：7

共 31 条

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