Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy

被引：56

作者：

Cerminara, C ^{[1
]}

Montanaro, ML ^{[1
]}

Curatolo, P ^{[1
]}

Seri, S ^{[1
]}

机构：

[1] Tor Vergata Univ, Div Neurosci, Dept Dev Neurol & Psychiat, I-00162 Rome, Italy

来源：

NEUROLOGY | 2004年 / 63卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000130195.62670.A6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine- induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.

引用

页码：373 / 375

页数：3

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