Cutting edge: Impaired transitional B cell production and selection in the nonobese diabetic mouse

被引：36

作者：

Quinn, William J., III ^{[1
]}

Noorchashm, Negin ^{[1
]}

Crowley, Jenni E. ^{[1
]}

Reed, Amy J. ^{[1
]}

Noorchashm, Hooman ^{[1
]}

Naji, Ali ^{[1
]}

Cancro, Michael P. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF IMMUNOLOGY | 2006年 / 176卷 / 12期

关键词：

D O I：

10.4049/jimmunol.176.12.7159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive clones. We analyzed B cell kinetics in the NOD mouse to establish whether these checkpoints are intact. Our results show that although bone marrow production is normal in NOD mice, transitional (TR) B cell production collapses at 3 wk of age, reflecting a lack of successful immature B cell migration to the periphery. This yields delayed establishment of the follicular pool and a lack of selection at the TR checkpoint, such that virtually all immature B cells that exit the bone marrow mature without further selection. These findings suggest that compromised TR B cell generation in NOD mice yields relaxed TR selection, affording autoreactive specificities access to mature pools.

引用

页码：7159 / 7164

页数：6

共 30 条

[1] Transient insulin autoantibody expression independent of development of diabetes: Comparison of NOD and NOR strains [J].