Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques

被引：23

作者：

Bernstein, Hans-Gert ^{[1
]}

Dobrowolny, Henrik ^{[1
]}

Keilhoff, Gerburg ^{[2
]}

Steiner, Johann ^{[1
]}

机构：

[1] Otto v Guericke Univ Magdeburg, Dept Psychiat, Leipziger Str 44, D-39120 Magdeburg, Germany

[2] Otto v Guericke Univ Magdeburg, Inst Biochem & Cell Biol, Leipziger Str 44, D-39120 Magdeburg, Germany

来源：

NEUROCHEMISTRY INTERNATIONAL | 2018年 / 114卷

关键词：

DPP IV; Amyloid; Neurons; Immunohistochemistry; Alzheimer's disease; DPP-4; INHIBITOR; SITAGLIPTIN; DEMENTIA; INSULIN; BETA;

D O I：

10.1016/j.neuint.2018.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：55 / 57

页数：3

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